VDJtools is an excellent tool for comprehensive comparative post analysis of T-cell receptor repetoires.

The software computes a wide set of statistics and is able to perform various forms of cross-sample analysis. Both comprehensive tabular output and presentation/publication-ready plots are provided.

Before VDJtools most of the analysis of this kind was done using in-house scripts, which inevitably led to reinventing the wheel and loss of analysis reproducibility.

The aims of VDJtools are:

VDJtools accepts tabular output of commonly used pre-processing software: MIGEC, MiXCR, MiTCR, ImmunoSEQ, and IMGT/HighV-QUEST.

Please see documentation for details.

Cite VDJtools as:

Shugay M et al. VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires. PLoS Comp Biol 2015; 11(11) doi: 10.1371/journal.pcbi.1004503.

For commercial use please contact licensing@milaboratory.com.

Image from Shugay et al., 2015, PLoS Comp Biol, doi: 10.1371/journal.pcbi.1004503.